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Sovaldi (Sofosbuvir)

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Sovaldi

Sovaldi is a drug used as part of antiviral therapy in people infected with the hepatitis C virus genotype 1, 2, 3 or 4 with HCV/HIV-1 co-infection or those who have hepatocellular carcinoma (HCC) and are awaiting a transplant. The medicine helps to reduce the virus amount in the body and is best suited for patients of 18 years and beyond.

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Approximate Delivery Date:
August, 13 - August, 22
Approximate Delivery Date:
July, 31 - August, 06

In Stock

Sovaldi 400mg; 28 pills bottle

1 bottle
£759.57 per bottle
£759.57 £949.47 per bottle

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General Info

Sovaldi is a drug used as part of antiviral therapy in people infected with the hepatitis C virus genotype 1, 2, 3 or 4 with HCV/HIV-1 co-infection or those who have hepatocellular carcinoma (HCC) and are awaiting a transplant. The medicine helps to reduce the virus amount in the body and is best suited for patients of 18 years and beyond.

Sovaldi
Active Ingredient

Sofosbuvir.

Description

Sovaldi is used together with other antiviral medications to treat a long-lasting HCV infection of the liver. The medicine’s main component is Sofosbuvir, an inhibitor of the hepatitis C virus nucleotide analog NS5B polymerase, indicated for the treatment of genotype 1, 2, 3, or 4 chronic HCV infection in patients with hepatocellular carcinoma (HCC) who are waiting to get a liver transplant, including those who are co-infected with human immunodeficiency virus (HIV-1). The medication operates by decreasing the amount of HCV in the body enabling the virus to spread and infect more cells.

Sovaldi must be administered in combination with either Peginterferon alfa or Ribavirin, or some other medicines (e.g., Daclatasvir, Ledipasvir, Simeprevir, Velpatasvir). Sovaldi-containing therapy regimen helps remove the virus from the blood over a period of time, thereby promoting liver recovery and improving its overall function.

One should take necessary precautions as the anti-hepatitis C treatment does not prevent the spread of infection to other people through their exposure to contaminated or potentially contaminated blood or body secretions.

Indications

Concomitant therapy of:

  • Chronic hepatitis C virus (HCV) infection (genotype 1, 2, 3 or 4).
  • HCV infection in patients with hepatocellular carcinoma (HCC) awaiting liver transplantation.
  • HCV/HIV-1 co-infected patients.
MOA (mechanism of action)

Sofosbuvir is a direct-acting antiviral (DAA) substance which inhibits the HCV NS5B RNA-dependent RNA polymerase, an essential enzyme for the viral replication process. The active ingredient is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active analog triphosphate (GS-461203). The active form of Sofosbuvir then interferes with the viral activity of naturally occurring nucleotides, competing for the incorporation into the HCV RNA where it can terminate the viral chain and therefore stop the virus from multiplying and spreading throughout the body.

Dosage

The regimen of Sovaldi-containing therapy and duration are dependent on both viral genotype and patients’ condition. It is recommended to administer the drug under medical supervision and advice. Before initiating the treatment, patients should take blood tests to check for the hepatitis C virus presence and/or drug resistance probability. The medication should be administered via the oral route only without regards to meals. The tablets are to be swallowed whole with a glassful of water. Do not chew, crush or break them.

The dosings of Ribavirin and Peginterferon alfa should be adjusted for each patient individually according to the body weight. Ribavirin must be taken orally twice a day, and Peginterferon alfa - injected under the skin.

Dosage should be adjusted in patients with a creatine clearance rate of less than 50 ml/min. Sovaldi intake must be discontinued if one of the concomitant therapy agents is permanently withdrawn. The anti-hepatitis combination treatment regimen should not be disrupted or stopped because it may lead to the disease exacerbation.

Missed dose

If you miss a dose of Sovaldi you should take it as soon as you remember. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Overdose

If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 20°C and 25°C (68°F and 77°F) away from excess moisture and heat. Do not use the medication if the seal is missing or broken. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Safety Information

Side effects

The most common side effects associated with Sovaldi are

  • tiredness
  • irritability
  • headache
  • dizziness
  • feeling or being sick
  • diarrhea
  • vomiting
  • loss of appetite
  • itchy and/or dry skin
  • skin rash
  • difficulty sleeping
  • anemia (low number of red blood cells)
  • thrombocytopenia (low number of blood platelets)
  • neutropenia (low number of white blood cells)
  • bradycardia (slow heartbeat)
  • dyspnea (shortness of breath)
  • cough
  • muscle pain and cramps

Side effect occurrence does not only depend on medication you are taking but also on your overall health and other factors.

Contraindications

Sovaldi is contraindicated in patients with known hypersensitivity to any of the components of this medicinal product.

Do not use the medicine without other antiviral agents in the chronic HCV infection treatment regimen.

Do not take the drug if you have been infected with the hepatitis B virus (HBV) as the anti-hepatitis C infection treatment may provoke HBV multiplication again.

Do not administrate Sovaldi in patients with serious kidney disorders or those who are currently undergoing dialysis.

Do not use the medication if you have one of the rare genetic diseases like galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

Do not use the drug during pregnancy or when breastfeeding without medical consultation.

Do not take Sovaldi if you are younger than 18 years of age without a doctor’s advice.

Other medicines

Do not take Sovaldi concomitantly with:

  • anticonvulsants (such as carbamazepine, oxcarbazepine, phenytoin)
  • medications to treat irregular heartbeat (like amiodarone)
  • sleep modification or insomnia medicines (such as phenobarbital or modafinil)
  • drugs to treat tuberculosis (e.g., rifabutin, rifampin)
  • medicinal products containing St. John’s Wort
  • blood thinners (like warfarin)
Delivery Information
Destination Service Tracking Delivery Time Price
Worldwide Not trackable 14-21 working days £12.07 per order
Trackable, where available 5-9 working days £20.11 per order

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Sovaldi

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Sovaldi is a drug used as part of antiviral therapy in people infected with the hepat...

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